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The problem is, though, that in functional B12 deficiency, dietary choline is taken up by the liver and used as a source of methyl groups through the action of the enzyme Betaine-homocysteine-S-methyltransferase (BHMT), thus lowering the supply of choline in the brain

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Systematic review on daily vitamin B 12 losses and bioavailability for deriving recommendations on vitamin B 12 intake with the factorial approach